Objective: The objective of the present study was to investigate the factors affecting the success and economic sustainability of home business support projects implemented by clients under the coverage of the Tonekabon County Welfare Organization. Method: The present study is of a descriptive-correlational type. The statistical population of this study included 204 clients under the coverage of the Tonekabon County Welfare Organization who received employment loans from the Tonekabon County Welfare Organization during the years 1400 to 1404. They were selected as the sample size using a simple and accessible random sampling method. In order to collect data, a 27-question questionnaire on factors affecting the success and economic sustainability of home business support projects (researcher-made) was used, which has good validity and reliability. All statistical analyses were performed using SPSS and PLS computer software. Findings: The results of data analysis show that there is a significant relationship between the factors affecting the success and economic sustainability of home-based business support projects for clients covered by the Tonekabon County Welfare Organization. Conclusion: Given the increasing role of home-based businesses in empowering and self-sufficiency of the less privileged in society and as a result of the dynamism of the country's economy and society, accurate identification of the factors affecting the development of this sector is of great importance.